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#0 dbbase_sql->halt(Invalid SQL: select * from kra_comment where pid='160006' and iffb='1' order by id limit 0,10) called at [E:\phpweb\phpwebsite\1011kra\63965966\includes\db.inc.php:54] #1 dbbase_sql->query(select * from {P}_comment where pid='160006' and iffb='1' order by id limit 0,10) called at [E:\phpweb\phpwebsite\1011kra\63965966\comment\module\CommentContent.php:167] #2 CommentContent() called at [E:\phpweb\phpwebsite\1011kra\63965966\includes\common.inc.php:551] #3 printpage() called at [E:\phpweb\phpwebsite\1011kra\63965966\comment\html\index.php:13] 留言点评--陆亿人软件开发
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发布于:2019-8-9 12:31:58  访问:69 次 回复:0 篇
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Is success, even so, is not really to rely on fast simulations in general
These kinds of simulations can push the atom count to perfectly around PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/27513814 1,000,000, which stops extended sampling. Can it be worthy of PubMed ID:https://www.ncbi.nlm.nih.gov/pubmed/23566152 the computational exertion then, to conduct an incredibly CP 4055 custom synthesis massive simulation and trust in success from just one trajectory? Below we critique the case of fibrinogen, which expected calculations with a process size of about 1 million atoms and serves as an case in point of how simulations of huge systems have triggered critical discoveries concerning the mechanical behavior of proteins with elaborate architectures. This circumstance also illustrates the end result of the strenuous work in sampling when every single simulation is very expensive. Fibrinogen is a protein that includes a most important building block of blood clots. Blood clots are important to stem bleeding during the celebration of mechanical injury, but can also impede blood flow when they kind or grow to be lodged in the vessel, main to life-threatening pathologies which include heart attack and stroke. Comprehension the mechanical properties of the fibrin blood clot, consequently, is of remarkable significance for creating therapies to possibly disrupt clots that have blocked significant vessels, or prevent them from forming in the first place (Weisel, 2004, 2005). Fibrinogen, schematically shown in Figure 2B, is transformed to fibrin by peptide cleavage, forming then a mesh-like community that in live performance with platelets, traps red blood cells to stem the stream of blood. During clot formation, fibrinogen molecules can bind each along the longitudinal and latitudinal axes (Doolittle, 1984; Weisel, 2005). Crystallography, spectroscopy, and biochemical scientific studies have revealed that a fibrinogen molecule is made up of numerous distinct domains arranged linearly (Yang et al., 2001), the central area of fibrinogen (called the E region, Figure 2B) currently being flanked on each side by lengthy helical domains which them selves are capped for the ends with -strand domains. AFM (Liu et al., 2006) and optical tweezer (Collet et al., 2005) reports have attributed extraordinary elasticity to fibrin fibers, which are equipped to stretch two to 6 situations their resting size prior to rupture. While such experiments reveal macroscopic details with regards to the relative stiffness or elasticity from the linear fibril staying stretched, they don‘t reveal where by stiffness or elasticity originate from during the protein and the way the 2 houses is usually chemically modified.Is good results, having said that, just isn‘t to believe in fast simulations normally, as I91 is plainly a fortuitous situation with a rupture occasion induced by smaller extension. In case of rupture occasions demanding bigger extension, quickly stretching may possibly direct a procedure into an alternative rupture pathway with then misleading conclusions. On the other hand, the naive viewpoint typically voiced that better (than experimentally noticed) rupture forces in simulations suggest an incorrect system is demonstrated wrong by the I91 example. This example, without a doubt, demonstrates the computational microscope at its ideal: it extends and describes AFM observation, revealing the structural features actually associated with protein mechanics.NIH-PA Creator Manuscript NIH-PA Author Manuscript NIH-PA Writer ManuscriptReproducible Simulations of a Pretty Big Process, FibrinogenSome mechanical proteins consist of intricately interwoven components exhibiting individually quite various elasticity.
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